TMCO1 and posterior cortical atrophy: After that, we looked at how recombinant protein CALR and TMCO1 knockdown affected human PCa cells and found that the migration, invasion and proliferation abilities of DU145 and PC-3 were significantly enhanced after CALR recombinant protein, and also had an impact on the intensity of intracellular calcium ions, ER probe and mitochondrial fluorescence probe.