CNR1 and schizophrenia: As a consequence, there is an augmentation in presynaptic dopamine in areas with an increased presence of CB1R in GABAergic neurons, such as in the cortex or striatum (Borgan et al., 2021; Szabó et al., 2014), which has been associated with the presence of positive symptoms (Borgan et al., 2021) and schizophrenia itself (Fusar-Poli and Meyer-Lindenberg, 2013).