On the other hand, the CB1R-Cav2.2 binomial is also able to suppress glutamate release in the hippocampus and anterior cingulate cortex through a similar mechanism of action (depolarization-induced suppression of excitation phenomenon) (Borgan et al., 2021), which has been associated with the occurrence of delusions and hallucinations (Egerton and Stone, 2012) and the presence of depression (Moriguchi et al., 2019; Duman et al., 2019). This evidence concerns the gene CACNA1B and major depressive disorder.