Advanced age, male gender, Mexican-American, married or living with a partner, living alone, former-smoker, heavy-drinker, inactive physical activity, higher total energy intake, BMI, PLT, ALT, AST, UA values, and DM, hypertension, MetS-ATP, CKD, CVD disease were positively associated with FLI, whereas college or above education level, higher PIR, and albumin were negatively related to FLI (all p value <0.05) (Supplementary Table S1). The gene discussed is ALB; the disease is chronic kidney disease.