CTLA4 and rheumatoid arthritis: F: Female; M: male; DMARDs: disease-modifying antirheumatic drugs,; HDL: high-density lipoprotein; LDL: low-density lipoprotein; CAC: coronary artery calcium; TNF-α: tumor necrosis factor alpha; IL6: interleukin 6; CTLA4-Ig: cytotoxic T lymphocyte-associated antigen-4-Ig; CD20; JAK: Janus kinase; NSAIDS: nonsteroidal anti-inflammatory drugs; RA: rheumatoid arthritis