The most frequent serologic studies findings include positive ANA, which has been reported in more than 80% of patients in most series of childhood SS; anti-Ro antibodies (SSA) that are found in more than 70% of patients in most reports; or anti-La (SSB) antibodies, which are detected in 30% to 70% of cases; and elevated ESR. The gene discussed is CALR; the disease is synovial sarcoma.