CD4 and Hand-foot syndrome: In conclusion, regarding ORR, QOL dichotomous variables, as well as thrombocytopenia, nausea and vomiting, diarrhea, and hepatorenal dysfunction, CD3+T Cells, CD4+T Cells, CD8+T Cells, CD4+CD8+T Cells, the quality was moderate; DCR, Neutropenia, Anemia, Skin Toxicity, Stomatitis, Neurotoxicity, Hand-Foot Syndrome, Alopecia, and KPS, according to mean ± SD had very low results (Table 7).