Interestingly, a description of a ‘glycogen-addicted’ signature in clear cell carcinomas includes overexpression of common mediators of the glycogenesis pathway (i.e. RAB25, GLUT1, protein kinase B (AKT), GSK3, and AMP-activated protein kinase) (15, 17, 23). This evidence concerns the gene AKT1 and clear cell adenocarcinoma.