In the pathological state of hyperglycemia generated by STZ, overexpression of G6Pase and increased G6Pase activity have been reported (Marcolongo et al., 2013; Govindarajan et al., 2021), leading to the release of substantial amounts of glucose from gluconeogenesis or glycogenolysis into the bloodstream, as observed in the control hyperglycemic group, where blood glucose levels increased over time (Figure 5C). The gene discussed is G6PC1; the disease is Hyperglycemia.