Subsequent phytochemical studies revealed that the main compound in C. guatemalensis is junceic acid, a diterpene with a clerodane skeleton whose pharmacological effects related to diabetes have not been reported in the literature; furthermore, rutin and epicatechin, two flavonoids that have been shown to have an insulin secretagogue effect, were also identified (Escandón-Rivera et al., 2022; Wen et al., 2022). This evidence concerns the gene INS and diabetes mellitus.