CCND1 and breast cancer: Furthermore, reports showed that kaempferol (23) elicited in vitro and in vivo anticancer activity against breast cancer by down-regulating the expression of cyclin D1, cyclin E, cathepsin D, pIRS-1, pAkt, and pMEK1/2, while up-regulating p21 and Bax expression (Kim et al., 2016).