Moreover, the alkaloid cryptolepine (28) (Figure 1) isolated from the methanol extract prepared from the whole plant and tested at concentrations of 1.25, 2.5 and 5 μM was able to solve tumor necrosis factor (TNF)-related apoptosis-inducing ligand resistance in human gastric adenocarcinoma (AGS) cell lines. This evidence concerns the gene TNF and gastric adenocarcinoma.