IL2 and neoplasm: Despite IL-2 being recognized for its critical role in immune system activation and induction of tumor cell death through Fc γ receptor binding, our meta-analysis revealed lower ORR and DCR when combined with IL-2, with respective values of 0.160 (95% CI: 0.066-0.342) and 0.522 (95% CI: 0.353-0.686), compared to non-combined scenarios (ORR 0.330, 95% CI: 0.223-0.459; DCR 0.665, 95% CI: 0.566-0.751) (47).