WFS1 and neoplasm: By integrating data from the TCGA and Gene Expression Omnibus (GEO) and utilizing advanced bioinformatics methods, we performed a comprehensive analysis of the relationship between WFS1 gene expression and EC, considering differential expression, prognostic modeling, functional enrichment analysis, gene mutation profiling, assessment of immune cell infiltration, IPS, tumor stemness index scoring, drug sensitivity analysis, single-cell transcriptomic analysis, glycolytic pathway analysis, and clinical validation.