The roles of several signature genes, including GPR115 (47), TCN1 (48), COL11A1 (49), RHOV (50), DKK1 (51), SLC34A2 (52), LGR5 (53), SOAT2 (54), and CDH17 (55), in the tumorigenesis of NSCLC have been well established, with some emerging as potential therapeutic targets. The gene discussed is TCN1; the disease is non-small cell lung carcinoma.