The roles of several signature genes, including GPR115 (47), TCN1 (48), COL11A1 (49), RHOV (50), DKK1 (51), SLC34A2 (52), LGR5 (53), SOAT2 (54), and CDH17 (55), in the tumorigenesis of NSCLC have been well established, with some emerging as potential therapeutic targets. This evidence concerns the gene LGR5 and non-small cell lung carcinoma.