ISG15 and discoid lupus erythematosus: reported a significant correlation between the expression levels of five IFN-I-regulated genes and the severity of skin manifestations in SLE patients with subacute cutaneous lupus erythematosus (SCLE) and discoid lupus erythematosus (DLE) (50); these genes included lymphocyte antigen 6 complex (LY6E), 2’,5’-oligoadenylate synthetase 1, OAS1, 2’,5’-oligoadenylate synthetase-like (OASL), ISG15 and myxovirus resistance 1 (MXI1).