The authors reported that whole-blood samples from SLE patients with high IFNGS expression were enriched with several inflammation-associated signaling markers, such as CD40L, CXC cytokines, TLR8-mediated monocyte activation, major histocompatibility complex class I, and the plasma cell gene expression signature, compared with patients with low IFNGS expression (38). Here, TLR8 is linked to systemic lupus erythematosus.