Figure 11D demonstrates that the apoptosis rate of tumor cells notably increased after PTMA knockdown. Furthermore, PTMA knockdown significantly raised the expression of the apoptosis-promoting proteins Bax and c-caspase3 while lowering the expression of the apoptosis-inhibiting protein Bcl-2, according to Western blot data (Figure 11E). The gene discussed is BAX; the disease is neoplasm.