CD4+CD25+ Treg cells expressing forkhead box protein p3 (Foxp3) are responsible for maintaining immune self-tolerance and immune homeostasis, which modulate the transcription of Foxp3 in the presence of the enhancer conserved non-coding sequence 1 (CNS1) to determine the differentiation of the Treg profile, hence preventing autoimmunity and maintaining immune homeostasis through amplification (71). Here, FOXP3 is linked to Autoimmunity.