A prior study also unveiled that intestinal dysbacteriosis and Th17-mediated intestinal mucosal immunity, as well as their characteristic cytokines IL-17A and IL-22, were also observed in CIA mice before the occurrence of arthritis and that antibiotic interventions alleviated arthritis modulated by intestinal ecology and mucosal immune imbalance (27). Here, IL22 is linked to arthritic joint disease.