In the present study, RPL23, FGFR1OP2, CAPN10, ALDH1L1 and ACSM1 were significantly downregulated in ovarian cancer, while the up-regulation of RPL23, FGFR1OP2, CAPN10 and ALDH1L1 was associated with poor prognosis in patients with ovarian cancer. The gene discussed is ACSM1; the disease is ovarian cancer.