PKM2, MRPS12, NDUFC2, HPDL, MRPL14, COA6 and RNF144B were significantly upregulated in ovarian cancer, but the down-regulation of NDUFC2, HPDL, MRPL14, COA6 and RNF144B was associated with poor prognosis in patients with ovarian cancer. The gene discussed is COA6; the disease is ovarian carcinoma.