In conclusion, a prognostic risk score model for ovarian cancer patients was constructed in this study based on PL23, PKM2, MRPS12, NDUFC2, HPDL, MRPL14, COA6, FGFR1OP2, RNF144B, CAPN10, ALDH1L1, and ACSM1. Here, RNF144B is linked to ovarian carcinoma.