In conclusion, a prognostic risk score model for ovarian cancer patients was constructed in this study based on PL23, PKM2, MRPS12, NDUFC2, HPDL, MRPL14, COA6, FGFR1OP2, RNF144B, CAPN10, ALDH1L1, and ACSM1. The gene discussed is NDUFC2; the disease is ovarian cancer.