In conclusion, a prognostic risk score model for ovarian cancer patients was constructed in this study based on PL23, PKM2, MRPS12, NDUFC2, HPDL, MRPL14, COA6, FGFR1OP2, RNF144B, CAPN10, ALDH1L1, and ACSM1. The gene discussed is PKM; the disease is ovarian carcinoma.