Compared with normal tissues, MRPS12, NDUFC2, HPDL, MRPL14, COA6 and RNF144B were significantly up-regulated in ovarian cancer tissues (P<0.05), RPL23, FGFR1OP2, CAPN10, ALDH1L1 and ACSM1 were significantly down-regulated (P<0.05) and the up-regulation of PKM2 and NDUFC2 was no significant (Figure 4).The treatment status of the sample of 8 patients is shown in Supplementary Table 3. The gene discussed is ACSM1; the disease is ovarian cancer.