Possible mechanisms linking physical activity and cognitive function in diabetic patients: on the one hand, it may be due to the neurotoxicity of hyperinsulinemia, where increased insulin sensitivity after physical activity may favors neurogenesis and thus cognitive function (40); on the other hand, the energy expenditure associated with physical activity may reduce cognitive deficits resulting from insulin resistance through vascular mechanisms (41). This evidence concerns the gene INS and Cognitive impairment.