β-amyloid (Aβ) plaques and tau neurofibrillary tangles are known pathological markers of AD (Sisodia and Price, 1995; Hampel et al., 2021), and it has been suggested that there is an interaction between the aggregation of these two and iron deposition (Galante et al., 2018; Liu et al., 2018), which together contribute to the development of AD and affect its cognitive function. This evidence concerns the gene MAPT and Alzheimer disease.