Given the adverse effects of persistent low thyroid hormone levels in patients with post-stroke cognitive dysfunction (Gkantzios et al., 2023; Lei et al., 2019; Li et al., 2021; Mei et al., 2022; Murolo et al., 2022), here is a clinical need to identify a safe and effective way to intervene early in such patients to improve their functional prognosis and quality of survival. This evidence concerns the gene TG and Stroke.