In this study, we observed a downregulation of Pten expression in the uteri of mice with endometriosis, which is in line with the previously published data showing that sporadic mutation or inactivation of Pten was found in endometriosis or endometrial hyperplasias (Tashiro et al. 1997; Sato et al. 2000; Govatati et al. 2014; Yang et al. 2021; Yang et al. 2016). Here, PTEN is linked to endometriosis.