CXCL12 and neoplasm: Multiple groups have demonstrated that, in mice,T cells can continuously egress the tumor via peritumoral lymphaticsto the TDLN.59,60 Recent investigation into thisphenomenon has shown that the LECs that comprise peritumoral lymphaticsupregulate CXCL12, influencing how different qualities of T cell areeither retained at the tumor site or induced to egress the tumor.61