For example, tumor-directed radiotherapy has been shown preclinicallyto generate an abscopal effect that correlates with enhanced CD8+T cell proliferation in the TDLN, but only if the TDLN itself is sparedirradiation.41 The generation of potentimmune responses in TDLNs, then, is important for eliciting systemicimmunity and treating distant tumors. Here, CD8A is linked to neoplasm.