Recently, Schindler’s research team usedHPLC coupled toICP-MS to assess the in vitro stability of severalnonradioactive lutetium- and gallium-labeled PSMA-targeting conjugates,including DOTA-PSMA-617 and HBED-PSMA-11 (Figure 5).9 It is worthnoting that 68Ga-labeled HBED-PSMA-11 is a widely usedradiotracer in PET imaging for prostate cancer.52−56 Traditionally, stability studies of radiopharmaceuticals/radioconjugatesin blood serum use HPLC equipped with a γ-detector to monitorthe degradation process.57 However, intheir work, Schindler et al. employed HPLC coupled to a ICP-MS. This evidence concerns the gene FOLH1 and prostate carcinoma.