POMC and Cachexia: In particular, ghrelin resistance has been suggested as a possible mediator, that may explain, in part, appetite losses in patients with cachexia [2, 3], while a decrease in neuropeptide Y (NPY) and proopiomelanocortin (POMC) expression has been implicated in Transforming growth factor beta (TGF‐b) mechanisms [4], affecting central appetite regulation.