APC and neoplasm: A tumour model based on Villin-creER;Apcfl/+;Rosafl/Confetti (hereafter Apchet;Confetti) mice and N-ethyl-N-nitrosourea (ENU) mutagenesis was adopted, that combined tissue-wide monoallelic loss of Apc with sporadic activation of the Confetti reporter (Fig. 1a).