AKR1C1 and neoplasm: Our results indicated that AKR1C1 was positively expressed in 70.9% (39/55) of the ECC tumor samples compared with matched adjacent tissues (Table 1), and AKR1C1 protein expression was positively corrected with histologic grade (P = 0.007, Fig. 2B) and Tumor-Node-Metastasis (TNM) stage (P = 0.0038, Fig. 2C) of tumors, whereas it had no significant correlation with sex or age.