While some studies question whether NMDA-receptors are internalized after binding of IgA/M NMDAR1-abs [47, 48], evidence shows at least IgA binding to hippocampal NMDA receptors, however, with lower affinity than IgG, possibly leading to local ‘latent’ autoimmunity [14, 41, 49]. The gene discussed is GRIN1; the disease is Autoimmunity.