Interestingly, recent reports showed that a similar negative relationship between Notch signaling and SOX2 has been inferred for neuroendocrine transformation of lung and prostate cancer, in which SOX2 induces or maintains lineage plasticity towards the neuroendocrine cell state, while Notch signaling would prevent neuroendocrine tumor growth or transformation (Quintanal-Villalonga et al, 2021, 2023; Mu et al, 2017; Puca et al, 2019; Ku et al, 2024). The gene discussed is SOX2; the disease is Familial prostate cancer.