Interestingly, recent reports showed that a similar negative relationship between Notch signaling and SOX2 has been inferred for neuroendocrine transformation of lung and prostate cancer, in which SOX2 induces or maintains lineage plasticity towards the neuroendocrine cell state, while Notch signaling would prevent neuroendocrine tumor growth or transformation (Quintanal-Villalonga et al, 2021, 2023; Mu et al, 2017; Puca et al, 2019; Ku et al, 2024). This evidence concerns the gene SOX2 and neuroendocrine neoplasm.