Similar to DAGs, SPH and its derivatives such as CER and S1P were previously characterized in this study for the M–D transition and colon cancer and, thus, do not require further elaboration, although the presence of two SHM components among the top ten covarying lipids with the dysplastic factor adds further evidence that this compound and its collaborators are important in precancerous progression. This evidence concerns the gene MBTPS1 and malignant colon neoplasm.