Other top proteomic pathways (Fig. 3a) included nuclear receptor signaling pathways LXR and RXR activation (−log10FDR = 20.40) and FXR and RXR activation (−log10FDR = 17.90), a cellular stress or injury GP6 signaling pathway (−log10FDR = 12.50), a humoral immune response complement system (−log10FDR = 11.80) pathway and disease-specific pathways atherosclerosis signaling (−log10FDR = 11.20) and hepatic fibrosis and hepatic stellate cell activation (−log10FDR = 10.70). This evidence concerns the gene NR1H4 and atherosclerosis.