The 39 pathways depicted in Fig. 3a display a selection of enriched pathways with high concordance across transitions in the proteome and between the transcriptome and proteome; these pathways were among the most significant and relevant enrichments spread across a diverse group of cellular and molecular functions, including pathways relevant to CRC such as CRC metastasis signaling (−log10FDR = 6.03), PLC signaling and FXR and RXR activation, which was shown to antagonize Wnt and β-catenin signaling in CRC tumorigenesis23. This evidence concerns the gene HSPG2 and colorectal carcinoma.