To illustrate the connections between CRC related pathways in the M–D transition, six such pathways (IL-12 signaling and production in macrophages, PLC signaling, FXR and RXR activation, SP and sphingomyelin (SPH) metabolism, CER signaling and S1P signaling) were selected and a multiomic pathway diagram was constructed (Fig. 4). This evidence concerns the gene HSPG2 and colorectal carcinoma.