The motifs for TFs GRHL1, GRHL2, TFCP2 and HOXD13 were over-represented in open chromatin regions in both basal BC and LP cells, whereas several TFs, including YY1 and YY2, E2F1 and E2F4, SOHLH2, PROX1, OTX1, NFYC, THAP11, ZNF140 and CENPF showed further increase in enrichment in basal BC beyond that seen in LP cells. The gene discussed is E2F1; the disease is breast cancer.