Finally, we performed cell type deconvolution using CytoSPACE on 33 slides from four basal-like, eight luminal and one HER2 BCs and again observed increased abundance of exhausted CD8+ T cells in basal-like cancers (Fig. 3b and Extended Data Fig. 4)53.Taken together, this provides evidence of increased immunosuppression and exhaustion in T cells in basal-like breast tumors. This evidence concerns the gene CD8A and cancer.