Furthermore, aberrant Myc activation has been shown to induce OPN expression42and a general profibrotic role for Myc is further corroborated by a study on renal fibrosis, which demonstrated fibroblast activation by direct binding of Myc to the promoter of integrin αv, leading to alternative activation of TGFβ signaling44. Here, TGFB1 is linked to renal fibrosis.