Acetate supplementation, by restoring [acetyl CoA] and H3K9Ac expression in the promoter and regulatory regions of Ifng gene in Hif1α–/– T cells, enhances Ifng transcription and rescues IFN-γ production as well as tumor-killing capacity of Hif1α–/– T cells. The gene discussed is HIF1A; the disease is neoplasm.