In addition, intraperitoneal injection of 12S‐HETE did not rescue the abolishment of 12‐LOX inhibitor‐induced defective adaptive thermogenesis, which is in accordance with previous report of slight changes in 12S‐HETE in response to 12‐LOX block treatment.[22] In this regard, 12S‐HETE may play an important role in glucose uptake and insulin resistance but not in adaptive thermogenesis.[22, 27] Another study showed an unchanged level of 15‐HETE in mice and humans acutely treated with Mirabegron.[22] However, we found that 15‐HETE was significantly increased under chronic cold exposure. This evidence concerns the gene ALOX12 and Insulin resistance.