INS and obesity due to melanocortin 4 receptor deficiency: Although no difference in body weight and food intake or effects on  Glucose tolerance test (GTT) and Insulin tolerance test (ITT) were observed (Figure S8A,C–E Supporting Information), 15‐HETE‐treated DIO mice showed an increased trend of body temperature in the 15‐HETE group (Figure S8B, Supporting Information), suggesting a potential anti‐obesity role of 15‐HETE.