Notably, obesity has been identified as a chronic low‐grade inflammation disease characterized by the increase in endotoxins and release of pro‐inflammatory cytokines.[9, 10, 11] The endotoxin LPS is elevated in both the circulation and adipose tissue under obesity,[9, 12, 13] which is accompanied by decreases in the expression of uncoupling protein 1 (UCP1) in adipocytes.[8, 14, 15] The molecular mechanisms responsible for the impaired adaptive thermogenesis in chronic inflammation have not been fully elucidated yet. The gene discussed is UCP1; the disease is obesity due to melanocortin 4 receptor deficiency.