KLK3 and neoplasm: These nomograms combine clinical tumor stage, initial serum prostate-specific antigen (PSA) levels, tumor aggressiveness determined by the International Society of Urological Pathology (ISUP) Grade Group (or Gleason Score [GS]), and the percentage of positive cores identified in prostate biopsies for the prediction of lymph node invasion (LNI) risk [8–10, 13].