In autoimmune diseases, pro-inflammatory cytokines such as TNF-α and IL-6 are caused it to be elevated [16].Therefore, it is hypothesized that PMR may be induced by bacterial infections, where cytokines stimulate the expression of ferritin genes [17] and the production of antiferritin antibodies in response to infection [18, 19]. The gene discussed is TNF; the disease is bacterial infectious disease.