Meanwhile, in rats with glucocorticoid-induced osteoporosis submitted to periodontitis, ATV at 27 mg/kg decreased bone loss, reduced myeloperoxidase (MPO), TNF-α, IL-1β, IL-6, and IL-8, and increased IL-10, glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) levels. This evidence concerns the gene CXCL8 and periodontitis.