In this context, when we restore the expression/activation of IFITM3, PKR, and eIF4e by silencing HSV1 VHS and Us11, and observe HIV-1 replication returning to basal levels during co-infection, it suggests that HSV1-induced enhancement of HIV-1 replication may be linked to interferon pathway dysregulation. The gene discussed is EIF2AK2; the disease is coinfection.