VEGFA and central nervous system cancer: We hypothesized that MCT4/CD147 transporter complex mediated the biological characteristics of glioma cells in an Akt-dependent manner, and downregulation of MCT4/CD147 by siRNA interference decreased tumor size and the number of blood vessels, likely because of impaired tumor glycolytic metabolism and decreased VEGF production, mediated by decreased microenvironmental lactate concentrations.