We hypothesized that MCT4/CD147 transporter complex mediated the biological characteristics of glioma cells in an Akt-dependent manner, and downregulation of MCT4/CD147 by siRNA interference decreased tumor size and the number of blood vessels, likely because of impaired tumor glycolytic metabolism and decreased VEGF production, mediated by decreased microenvironmental lactate concentrations. Here, AKT1 is linked to central nervous system cancer.