PLA2R1 and membranous glomerulonephritis: On the other hand, Miller et al. described a patient with double positivity on immunohistochemistry to PLA2R and Semaphorin-3b (SEMA3b) autoantigens on renal biopsy, highlighting the fact that there may be other target antigens involved in the pathophysiology of IPEX-related membranous nephropathy [10,11].