SLC30A1 and Salmonella Infections: To examine the role of Slc30a1 in macrophages with respect to protecting against Salmonella infection, we generated the conditional knockout mice with a loss-of-function allele of Slc30a1 in myeloid cells including macrophages by crossing mice carrying a floxed Slc30a1 allele (Slc30a1fl/fl) with Lyz2-Cre recombinase mice (Figure 4A); we then used the homozygous floxed mice with heterozygous Cre (Slc30a1fl/fl;Lyz2-Cre or Slc30a1 cKO(Conditional knockout)), with homozygous floxed littermates lacking Cre (Slc30a1fl/fl) serving as a control group.