NK cells require activating receptors to recognize tumor cells; they require inhibitory receptors to tune their cytotoxic function in a process known as “licensing” or “education” (49–51), and many of the cytotoxic processes are controlled by the transcription factors T-bet and Eomes (52–54), so the loss of these factors likely impairs NK cell cytotoxicity. Here, EOMES is linked to neoplasm.