The serum contained a tumor- and Notch-dependent set of cytokines that overlapped with the circulating LY411575-dependent group [triggering receptor expressed on myeloid cells-1 (TREM-1), G-CSF, monocyte chemoattractant protein-5 (MCP-5), IP-10, IL-1β, TIMP-1, IL-1ra, CCL2, and IL-16; Fig. 4, B and C]. The gene discussed is IL1B; the disease is neoplasm.