Notably, recent studies have shown potential widespread involvement of DLK in neuronal death observed in neurotrophic factor deprivation, glaucoma, amyotrophic lateral sclerosis, and Alzheimer’s disease models (Pozniak et al., 2013; Welsbie et al., 2013; Welsbie et al., 2017; Larhammar et al., 2017a; Le Pichon et al., 2017; Patel et al., 2017). Here, MAP3K12 is linked to early-onset autosomal dominant Alzheimer disease.