Recent studies have implicated DLK as a central player in neuronal death, including in diseases such as Alzheimer’s disease and amyotrophic lateral sclerosis (Pozniak et al., 2013; Welsbie et al., 2013; Welsbie et al., 2017; Larhammar et al., 2017a; Larhammar et al., 2017b; Le Pichon et al., 2017; Patel et al., 2017). This evidence concerns the gene MAP3K12 and early-onset autosomal dominant Alzheimer disease.