Granulovacuolar degeneration, commonly associated with NFT pathology in the hippocampus and temporal cortex in human brain aging and AD, has been reported in the hippocampus and the medium-temporal lobe in six aged cynomolgus monkeys bearing P-tau Thr231 immunoreactivity in the cytoplasm of neurons of the temporal and occipital lobe [117, 223]. The gene discussed is MAPT; the disease is Alzheimer disease.