BRCA1 and ovarian carcinoma: BRCA1/BRCA2 PV carriers had elevated combined nonbreast/ovarian cancer SIRs (BRCA1: SIR, 2.18 [95% CI, 1.59 to 2.92]; BRCA2: SIR, 1.68 [95% CI, 1.24 to 2.23]).