BRCA2 and cancer: Male BRCA2 PV carriers had elevated CBC (SIR, 431 [95% CI, 48.5 to 1,559]), pancreatic (SIR, 20.2 [95% CI, 4.07 to 59.1]), and prostate (SIR, 4.46 [95% CI, 1.79 to 9.19]) cancer SIRs.