BRCA1 PV carriers were at increased CBC (HR, 3.60 [95% CI, 2.65 to 4.90]), OC (HR, 33.0 [95% CI, 19.1 to 57.1]), colorectal (HR, 2.93 [95% CI, 1.53 to 5.62]), and nonbreast/ovarian (HR, 1.45 [95% CI, 1.05 to 2.01]) cancer risks compared with noncarriers (Table 3). This evidence concerns the gene BRCA1 and cancer.