Another study in transformedhepatocellular carcinoma cells and transgenic mice expressing the Hepatitis B virus(HBV) pre-S2 mutant in the liver showed increased ACLY phosphorylation through mTORsignaling to induce the levels of neutral lipids such as triglycerides andcholesterol (90), without showing a directeffect of HBV infection on ACLY levels. Here, ACLY is linked to carcinoma.