ACLY and infection: Remarkably, we found that VACV infection increased ACLYphosphorylation at S455 in HFFs (Fig. 3C).Moreover, we found that VACV infection increased ACLY phosphorylation wasobservable at 2- and 8 h post-infection (hpi) (Fig. 3D), indicating that VACV can modulate ACLY activity startingearly during the infection.