Theexpression and activity of ACLY are significantly upregulated in severalmalignancies such as bladder, breast, lung, liver, stomach, prostate, and coloncancers (25, 29, –, 33), and the overexpression of ACLY correlateswith poor prognosis in lung adenocarcinoma and blood cancers (30, 34). This evidence concerns the gene ACLY and lung adenocarcinoma.