CREBBP and B-cell non-Hodgkin lymphoma: Activation of the ERK pathway serves as a stimulus for HSCs to exit the self‐renewal program and transition into the differentiation phase.[50] The loss of CREBBP in murine HSPCs results in an increased development of B‐cell lymphomas.[51] Indeed, in STAT3mut/mut mice, we observed a marked increase in both myeloid and lymphoid cells in peripheral blood.