TP53 and neoplasm: It has been well‐documented that perturbation of any crucial step of ribosome biogenesis may lead to nucleolar stress, also known as ribosomal stress.[8, 9, 10] Under this stress condition, a portion of RPs, particularly RPL5 and RPL11, is translocated from the nucleolus to the nucleoplasm, where they interact with MDM2 and inhibit its E3 ligase activity toward p53, consequently resulting in the activation of p53.[11, 12, 13, 14] In addition, nucleolar stress may lead to tumor suppression through p53‐independent signaling pathways.