The Brix (biogenesis of ribosomes in Xenopus) was first detected in frog and later found to participate in rRNA processing in yeast.[33, 34] The expression of human BRIX1 was recently shown to correlate with rRNA synthesis and promote the translation of GLUT1 in colorectal cancer.[35] However, the role and mechanism of BRIX1 in rRNA synthesis and cancer development remain largely elusive. Here, BRIX1 is linked to colorectal cancer.