TP53 and colorectal cancer: Meanwhile, we determined the clinical relevance of BRIX1 levels using colorectal cancer samples with low expression of p53, as p53‐low samples might contain wild‐type p53.[45] Our IHC analysis showed that BRIX1 was expressed at higher levels in colorectal cancer compared to normal tissues, whereas p21 was expressed at lower levels in colorectal cancer than normal tissues (Figure 6E–G).