BRIX1 and cancer: Our results revealed that overexpression of BRIX1 significantly increased the proliferation (Figure 4L,M) and colony formation (Figure 4N,O), while reduced apoptosis (Figure S3F,G, Supporting Information) of cancer cells when treated with a low dose of Act D. In addition, ectopic BRIX1 promoted the migration of cancer cells (Figure 4P,Q).