BRAF and melanoma: Dacarbazine (DTIC) is the chemotherapy drug indicated for melanoma, particularly in stages where surgical options are not viable and there are indications of migration or metastatic processes.[52] Vemurafenib (VEM) is an oral medication used in the treatment of cutaneous melanoma, specifically for patients whose tumors exhibit a mutation in the BRAF gene (most commonly the BRAF V600E mutation).[53] To include a more general chemotherapeutic agent, Paclitaxel (PTX) was selected for its action in melanoma,[54] especially in combination with other drugs.