Down‐regulation of Ets1 triggers EndMT and exacerbates blood‐brain barrier dysfunction in multiple sclerosis.[34] Furthermore, numerous investigations corroborate the crucial involvement of Ets1 in orchestrating EndMT progression.[35, 36] Nevertheless, there appears to be disparate roles for Ets1 in EndMT progression as reported by these studies, potentially due to variations in structural differences, microenvironmental conditions, and experimental design. This evidence concerns the gene ETS1 and multiple sclerosis.