Herein, a “double braking” strategy on mPTP by cyclosporin A (CsA) derived ionizable lipid with 3D structure (3D‐lipid) binding cyclophilin D (CypD) and siRNA downregulating mitochondrial calcium uniporter (MCU) expression is proposed for treating IPF. The gene discussed is MCU; the disease is idiopathic pulmonary fibrosis.